Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction

المؤلفون المشاركون

Brennecke, Shaun Patrick
Kalionis, Bill
Georgiou, Harry M.
Wookey, Alice F.
Chollangi, Tejasvy
Yong, Hannah E. J.
Murthi, Padma

المصدر

Journal of Pregnancy

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-15

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health.

Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties.

We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction.

Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR).

FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9).

Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration.

The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p<0.05, Student’s t-test) that were strongly associated with idiopathic fetal growth restriction (p<0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p=0.295, Pearson’s correlation).

As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wookey, Alice F.& Chollangi, Tejasvy& Yong, Hannah E. J.& Kalionis, Bill& Brennecke, Shaun Patrick& Murthi, Padma…[et al.]. 2017. Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction. Journal of Pregnancy،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1186073

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wookey, Alice F.…[et al.]. Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction. Journal of Pregnancy No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1186073

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wookey, Alice F.& Chollangi, Tejasvy& Yong, Hannah E. J.& Kalionis, Bill& Brennecke, Shaun Patrick& Murthi, Padma…[et al.]. Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction. Journal of Pregnancy. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1186073

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1186073