In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study
المؤلفون المشاركون
Nyarko, Alexander Kwadwo
Appiah-Opong, Regina
Appiah, Alfred A.
Bosompem, Kwabena M.
Penlap, Veronique
Tekwu, Emmanuel Mouafo
Anyan, William Kofi
Owusu, Kofi Baffour-Awuah
Tettey, Mabel Deladem
Kissi, Felicia Amanfo
المصدر
Journal of Parasitology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy.
The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds.
This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni.
Both plant parts were found to be active against cercariae and adult worms.
Within 2 h of exposure all cercariae were killed at a concentration range of 62.5–1000 µg/mL and 250–1000 µg/mL of R.
vomitoria stem bark and roots, respectively.
The LC50 values determined for the stem bark after 1 and 2 h of exposure were 207.4 and 61.18 µg/mL, respectively.
All adult worms exposed to the concentrations range of 250–1000 µg/mL for both plant parts died within 120 h of incubation.
The cytotoxic effects against HepG2 and Chang liver cell assessed using MTT assay method indicated that both plant extracts which were inhibitory to the proliferation of cell lines with IC50 > 20 μg/mL appear to be safe.
This report provides the first evidence of in vitro schistosomicidal potency of R.
vomitoria with the stem bark being moderately, but relatively, more active and selective against schistosome parasites.
This suggests the presence of promising medicinal constituent(s).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tekwu, Emmanuel Mouafo& Bosompem, Kwabena M.& Anyan, William Kofi& Appiah-Opong, Regina& Owusu, Kofi Baffour-Awuah& Tettey, Mabel Deladem…[et al.]. 2017. In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study. Journal of Parasitology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1186189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tekwu, Emmanuel Mouafo…[et al.]. In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study. Journal of Parasitology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1186189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tekwu, Emmanuel Mouafo& Bosompem, Kwabena M.& Anyan, William Kofi& Appiah-Opong, Regina& Owusu, Kofi Baffour-Awuah& Tettey, Mabel Deladem…[et al.]. In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study. Journal of Parasitology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1186189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر