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Smoking Is a Risk Factor of Coronary Heart Disease through HDL-C in Chinese T2DM Patients: A Mediation Analysis
المؤلفون المشاركون
Liu, Weiguo
Yang, Zhengguo
Wang, Shuang
Tang, Ru
Yang, Shanshan
Yang, Bo
He, Yao
المصدر
Journal of Healthcare Engineering
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To investigate associations between smoking and cardiovascular and cerebrovascular complications in type 2 diabetes mellitus (T2DM) patients.
Methods.
This is a cross-sectional study.
Of 971 T2DM patients aged 14–93 years old in this study, 182 had ever smoked and 789 never smoked.
Propensity score matching (PSM) reduced the confounding bias between groups.
Logistic regression analysis was performed on matched data to evaluate coronary heart disease (CHD) and stroke risk.
In addition, the mediation analysis was conducted among smoking exposure, HDL-C, and CHD.
Results.
A total of 139 pairs of patients who had never and ever smoked were matched.
Logistic regression analysis showed that compared with patients who never smoked, those who smoked > 20 cigarettes per day (CPD) had a higher risk of CHD (odds ratio [OR]: 3.09, 95% confidence interval [CI]: 1.21–7.89).
Additionally, after adjusting for age, sex, origin, occupation, smoking status, body mass index, waist circumference, and diabetes duration, the OR for CHD with >20 years of cumulative smoking (pack-years) was 2.21 (95% CI: 1.05–4.65).
Furthermore, we observed a significant dose-response relationship between CPD and lower high-density lipoprotein cholesterol (HDL-C) (P<0.001).
Moreover, the mediation analysis showed that the indirect effect mediated by HDL-C accounted for 86% (effect = 0.0187, 95% CI: 0.0100–0.0316).
Conclusions.
Smoking may be a risk factor for CHD in T2DM patients.
T2DM patients should stop smoking or reduce the CPD to prevent the onset of CHD.
Moreover, to prevent CHD complications, monitoring HDL-C levels in T2DM patients who smoke may be necessary.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Ru& Yang, Shanshan& Liu, Weiguo& Yang, Bo& Wang, Shuang& Yang, Zhengguo…[et al.]. 2020. Smoking Is a Risk Factor of Coronary Heart Disease through HDL-C in Chinese T2DM Patients: A Mediation Analysis. Journal of Healthcare Engineering،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Ru…[et al.]. Smoking Is a Risk Factor of Coronary Heart Disease through HDL-C in Chinese T2DM Patients: A Mediation Analysis. Journal of Healthcare Engineering No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1186602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Ru& Yang, Shanshan& Liu, Weiguo& Yang, Bo& Wang, Shuang& Yang, Zhengguo…[et al.]. Smoking Is a Risk Factor of Coronary Heart Disease through HDL-C in Chinese T2DM Patients: A Mediation Analysis. Journal of Healthcare Engineering. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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