Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix
المؤلفون المشاركون
Zhang, Youzhong
Chen, Jie
Zong, Liju
Zhang, Qianqian
Zhou, Yuncan
Kong, Yujia
Yu, Shuangni
Xiang, Yang
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subtype of cervical cancer).
We also compared the expression statuses of these biomarkers in cervical CCCs with those in cervical squamous cell carcinomas (SCCs).
We evaluated the expression of PD-L1, B7-H3, B7-H4, and VISTA in 50 cervical CCCs and 100 SCCs using immunohistochemical staining and investigated the associations between these markers, clinicopathologic features, and survival in patients with CCCs.
Of the cervical CCC samples examined, 22%, 16%, 32%, and 34% were positive for PD-L1, B7-H3, B7-H4, and VISTA, respectively.
Nineteen samples (38%) were negative for all 4 of these markers, whereas 31 (62%) expressed at least 1 marker.
None of these markers was associated with the investigated clinicopathologic variables or patient survival.
PD-L1, B7-H3, and VISTA were observed significantly more frequently in SCCs than in CCCs of the cervix.
Our study confirmed the expression of immune checkpoint proteins in cervical CCCs and indicated their nonredundant and complementary roles.
As such, our data suggest that monotherapeutic immune checkpoint blockade may not be sufficiently effective in patients with cervical CCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zong, Liju& Zhang, Qianqian& Zhou, Yuncan& Kong, Yujia& Yu, Shuangni& Chen, Jie…[et al.]. 2020. Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1186877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zong, Liju…[et al.]. Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix. Journal of Immunology Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1186877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zong, Liju& Zhang, Qianqian& Zhou, Yuncan& Kong, Yujia& Yu, Shuangni& Chen, Jie…[et al.]. Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1186877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر