Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia

الملخص EN

Laser hyperthermia is a powerful therapeutic modality that suppresses the growth of proliferative lesions.

In hyperthermia, the optimal temperature range is dependent on the disease; thus, a temperature-driven laser output control system is desirable.

Such a laser output control system, integrated with a thermal sensor circuit based on thermography, has been established.

In this study, the feasibility of the developed system was examined by irradiating mouse skin.

The system is composed of a thermograph, a thermal sensor circuit (PC and microcontroller), and an infrared laser.

Based on the maximum temperature in the laser-irradiated area acquired every 100 ms during irradiation, the laser power was controlled such that the maximum temperature was maintained at a preset value.

Temperature-controlled laser hyperthermia using the thermal sensor circuit was shown to suppress temperature fluctuations during irradiation (SD ~ 0.14°C) to less than 1/10 of those seen without the thermal sensor circuit (SD ~ 1.6°C).

The thermal sensor circuit was able to satisfactorily stabilize the temperature at the preset value.

This system can therefore provide noncontact laser hyperthermia with the ability to maintain a constant temperature in the irradiated area.