Predictors of Poor Outcome of Anti-MDA5-Associated Rapidly Progressive Interstitial Lung Disease in a Chinese Cohort with Dermatomyositis

الملخص EN

Objective.

Antimelanoma differentiation-associated protein 5 (anti-MDA5) autoantibody has been reported in dermatomyositis (DM) to be associated with rapidly progressive interstitial lung disease (RP-ILD).

Our study is aimed at determining the clinical characteristics and prognostic factors underpinning anti-MDA5-associated RP-ILD.

Methods.

Patients with anti-MDA5-associated DM (aMDA5-DM) were identified at the Peking University People’s Hospital.

The presence of anti-MDA5 antibody was determined by immunoblotting.

Kaplan-Meier, chi-square test, univariate, and multivariate data analyses were used.

Results.

Out of 213 patients with DM and clinically amyopathic dermatomyositis (CADM), 20.7% (44/213) of patients were identified as aMDA5-DM.

Amongst the aMDA5-DM patients, 63.6% (28/44) were identified as having anti-MDA5-associated RP-ILD.

During the follow-up, 32.1% (9/28) of patients with anti-MDA5-associated RP-ILD died of respiratory failure.

We identified older age and periungual erythema as two independent risk factors for RP-ILD mortality.

Age≥57 years at disease onset was significantly associated with poor survival (P=0.02) in patients with anti-MDA5-associated RP-ILD, while patients with periungual erythema had a better survival rate than those without periungual erythema (P<0.05).

Conclusions.

Anti-MDA5-associated RP-ILD is significantly associated with poor survival rates in DM/CADM patients.

More effective intervention should be administered to anti-MDA5-associated RP-ILD patients, especially to senior patients and those without periungual erythema.