miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes
المؤلفون المشاركون
Fotoh, Dina Salem
Noreldin, Rasha Ibrahim
Rizk, Mohamed Soliman
Elsabaawy, Maha Mohamed
Esaily, Heba Ahmed
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Early diagnosis of ankylosing spondylitis (AS) is yet not elucidated, with a potential diagnostic glance of microRNAs (miRNAs).
Aim.
Study the expression profile of miRNA-451a and miRNA-125a in AS patients and their impact on disease activity and prognosis.
Methods.
A cross-sectional study included 55 AS patients diagnosed according to modified New York criteria in 1984 with 55 matched healthy controls.
History, clinical examination, and disease activity assessment with Bath ankylosing spondylitis disease activity index (BASDAI) were done.
Full laboratory and radiological assessment along with expression profile of m iRNA-451a and miRNA-125a were tabulated and analyzed.
Results.
Higher expression levels of miRNA-125a and lower of miRNA-451a in AS patients compared to controls.
Furthermore, miRNA-125a expression was high in active AS patients compared to inactive patients and controls (7.0±3.4 vs.
4.1±2.1 vs.
2.6±0.6, p<0.001, respectively).
miRNA-451a was significantly lower in active AS patients compared to inactive patients and controls (2.2±1.1 vs.
4.1±2.3 vs.
7.1±4.5, respectively).
Both miRNAs (miRNA-125a and miRNA-451a) had evident accuracy for AS diagnosis with areas under the curve (AUC) of 0.788 and 0.802, respectively.
miRNA-125a had potential impact on AS activity with AUC of 0.777.
Plasma levels of both miRNAs were able to distinguish AS patients with structural damage with AUCs 0.775 and 0.692, respectively.
Conclusions.
Both miRNA-451a and miRNA-125a were found to be of great value as sensitive noninvasive diagnostic, prognostic, and disease burden biomarker of AS patients in Egypt with suggested further studies for future therapeutic implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fotoh, Dina Salem& Noreldin, Rasha Ibrahim& Rizk, Mohamed Soliman& Elsabaawy, Maha Mohamed& Esaily, Heba Ahmed. 2020. miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186992
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fotoh, Dina Salem…[et al.]. miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1186992
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fotoh, Dina Salem& Noreldin, Rasha Ibrahim& Rizk, Mohamed Soliman& Elsabaawy, Maha Mohamed& Esaily, Heba Ahmed. miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1186992
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186992
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر