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Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis
المؤلفون المشاركون
Balahura, Liliana R.
Selaru, Aida
Dinescu, Sorina
Costache, Marieta
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Over the past decade, it has been well established that tumorigenesis is affected by chronic inflammation.
During this event, proinflammatory cytokines are produced by numerous types of cells, such as fibroblasts, endothelial cells, macrophages, and tumor cells, and are able to promote the initiation, progression, and metastasis of different types of cancer.
When persistent inflammation occurs, activation of inflammasome complexes is initiated, leading to its assembly and further activation of caspase, production of proinflammatory cytokines, and pyroptosis induction.
The function of this multiprotein complex is not only to reassure inflammation and to promote cell death, through caspase activity, but also has been identified to have significant contributions during tumorigenesis and cancer development.
So far, many efforts have been made in order to extend the knowledge of inflammasome implications and how its components could be targeted as therapeutic agents.
Additionally, microRNAs (miRNAs), evolutionary conserved noncoding molecules, have emerged as pivotal players during numerous biological events by regulating gene and protein expression.
Therefore, dysregulations of miRNA expressions have been correlated with inflammation during tumor development.
In this review, we aim to highlight the dual role of inflammasomes and proinflammatory cytokines during carcinogenesis paired with the distinguished effects of miRNAs upon inflammation cascades during tumor growth and progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balahura, Liliana R.& Selaru, Aida& Dinescu, Sorina& Costache, Marieta. 2020. Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1187043
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balahura, Liliana R.…[et al.]. Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis. Journal of Immunology Research No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1187043
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balahura, Liliana R.& Selaru, Aida& Dinescu, Sorina& Costache, Marieta. Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1187043
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187043
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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