TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis
المؤلفون المشاركون
Granados, Julio
Fonseca-Camarillo, G.
Toledo Mauriño, Joel J.
Barreto-Zuñiga, Rafael
Martínez-Benítez, Braulio
Yamamoto-Furusho, Jesús K.
Furuzawa-Carballeda, Janette
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
TRPVs are a group of receptors with a channel activity predominantly permeable to Ca2+.
This subfamily is involved in the development of gastrointestinal diseases such as ulcerative colitis (UC).
The aim of the study was to characterize the gene and protein expression of the TRPV subfamily in UC patients and controls.
Methods.
We determined by quantitative PCR the gene expression of TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6 in 45 UC patients (29 active UC and 16 remission UC) and 26 noninflamed controls.
Protein expression was evaluated in 5 μm thick sections of formalin-fixed, paraffin-embedded tissue from 5 customized severe active UC patients and 5 control surgical specimens.
Results.
TRPV2 gene expression was increased in the control group compared with active UC and remission patients (P=0.002 and P=0.05, respectively).
TRPV3 gene expression was significantly higher in controls than in active UC patients (P=0.002).
The gene expression of TRPV4 was significantly higher in colonic tissue from patients with remission UC compared with active UC patients (P=0.05) and controls (P=0.005).
TRPV5 had significantly higher mRNA levels in a control group compared with active UC patients (P=0.02).
The gene expression of TRPV6 was significantly higher in the colonic tissue from patients with active UC compared with the control group (P=0.05).
The protein expression of TRPV2 was upregulated in the mucosa and submucosa from the controls compared with the UC patients (P≤0.003).
The protein expression of TRPV3 and TRPV4 was upregulated in all intestinal layers from the controls compared with the UC patients (P<0.001).
TRPV5 was upregulated in the submucosa and serosa from the controls vs.
UC patients (P<0.001).
TRPV6 was upregulated in all intestinal layers from the UC patients vs.
controls (P≤0.001).
Conclusion.
The TRPV subfamily clearly showed a differential expression in the UC patients compared with the controls, suggesting their role in the pathophysiology of UC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Toledo Mauriño, Joel J.& Fonseca-Camarillo, G.& Furuzawa-Carballeda, Janette& Barreto-Zuñiga, Rafael& Martínez-Benítez, Braulio& Granados, Julio…[et al.]. 2020. TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187090
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Toledo Mauriño, Joel J.…[et al.]. TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187090
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Toledo Mauriño, Joel J.& Fonseca-Camarillo, G.& Furuzawa-Carballeda, Janette& Barreto-Zuñiga, Rafael& Martínez-Benítez, Braulio& Granados, Julio…[et al.]. TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187090
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187090
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر