Clinical Significance of Serum Galactose-Deficient IgA1 Level in Children with IgA Nephropathy
المؤلفون المشاركون
Yachie, Akihiro
Shimizu, Masaki
Inoue, Natsumi
Mizuta, Mao
Irabu, Hitoshi
Kaneko, Shuya
Ohta, Kazuhide
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study was aimed at investigating the clinical significance of serum galactose-deficient IgA1 (Gd-IgA1) levels measured by a novel lectin-independent enzyme-linked immunosorbent assay (ELISA) using an anti-Gd-IgA1 monoclonal antibody (KM55) as a disease-specific biomarker for IgA nephropathy (IgAN) in children.
Thirty-three children with IgAN, 40 with non-IgA glomerular diseases, and 38 age-matched healthy controls (HCs) were enrolled.
Serum Gd-IgA1 levels were quantified by ELISA using KM55.
Results were statistically compared with clinical features and pathological findings of IgAN.
Serum Gd-IgA1 levels were significantly elevated in children with IgAN compared with children with non-IgA glomerular diseases and HCs.
Serum Gd-IgA1 levels in children with IgAN were positively correlated with serum total IgA levels.
However, the serum Gd-IgA1/total IgA ratio (Gd-IgA1/IgA) was also significantly elevated in children with IgAN.
Serum Gd-IgA1 levels in children with IgAN increased in an age-dependent manner.
The cutoff value of serum Gd-IgA1 levels for differentiating IgAN from non-IgA glomerular diseases was 3236 in children<12 years and 5284 in children≥12 years, respectively.
In contrast, serum Gd-IgA1/IgA was age-independent.
The cutoff value of serum Gd-IgA1/IgA for differentiating IgAN from non-IgA glomerular diseases was 0.2401.
Serum Gd-IgA1 levels were negatively correlated with eGFR and positively correlated with mesangial IgA deposition.
In contrast, serum Gd-IgA1/IgA levels were not correlated with any clinical parameters of IgAN.
In conclusion, serum Gd-IgA1 levels were significantly elevated in children with IgAN.
However, those levels were age-dependent; therefore, serum Gd-IgA1 levels classified by age and/or serum Gd-IgA1/IgA might have diagnostic values in children with IgAN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Irabu, Hitoshi& Shimizu, Masaki& Kaneko, Shuya& Inoue, Natsumi& Mizuta, Mao& Ohta, Kazuhide…[et al.]. 2020. Clinical Significance of Serum Galactose-Deficient IgA1 Level in Children with IgA Nephropathy. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Irabu, Hitoshi…[et al.]. Clinical Significance of Serum Galactose-Deficient IgA1 Level in Children with IgA Nephropathy. Journal of Immunology Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1187188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Irabu, Hitoshi& Shimizu, Masaki& Kaneko, Shuya& Inoue, Natsumi& Mizuta, Mao& Ohta, Kazuhide…[et al.]. Clinical Significance of Serum Galactose-Deficient IgA1 Level in Children with IgA Nephropathy. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر