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Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells
المؤلفون المشاركون
Li, Si-Zhe
Jin, Xin-Xing
Ge, Xiao-Lei
Zuo, Ya-Gang
Jin, Hong-Zhong
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified.
We sought to explore the contributions of TSLP and DCs in patients with BP.
Methods.
TSLP levels in sera and blister fluids were measured by enzyme-linked immunosorbent assay.
The TSLP expression in the BP lesional skin was detected by immunohistochemical staining.
Infiltration of DCs, marked by DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and its relationship with TSLP and TSLP receptors was evaluated by immunofluorescence staining.
Results.
We found that TSLP levels in sera and in blister fluids of patients with BP were higher compared to the control groups.
In patients with BP, TSLP levels in sera correlated with TSLP levels in blisters.
The expression of TSLP in the BP lesional skin was higher compared to the healthy controls’ skin.
Greater numbers of TSLP-positive cells were observed in the epidermis of patients with BP compared to the healthy controls.
Greater numbers of DC-SIGN-positive cells were present in the BP lesional skin compared to the skin of controls.
The expression of TSLP was highly upregulated in DC-SIGN-positive cells, and most DC-SIGN-positive cells expressed TSLP receptors.
Conclusions.
We conclude that TSLP may activate DC-SIGN-positive DCs directly, which may be involved in the pathogenesis of BP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Si-Zhe& Jin, Xin-Xing& Ge, Xiao-Lei& Zuo, Ya-Gang& Jin, Hong-Zhong. 2020. Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Si-Zhe…[et al.]. Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells. Journal of Immunology Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1187208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Si-Zhe& Jin, Xin-Xing& Ge, Xiao-Lei& Zuo, Ya-Gang& Jin, Hong-Zhong. Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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