Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications
المؤلفون المشاركون
Lu, Xue-Chun
Zhang, Ran
Wang, Haiming
Liu, Zifan
Shao, Junjie
Lin, Lejian
Jiang, Min
Wang, Lin
Zhang, Haomin
Chen, Yundai
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Acute coronary syndrome (ACS) is a major cause of acute death worldwide.
Both innate and adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus formation.
Immune and inflammation dysfunction have been indicated in the pathogenesis of ACS.
The imbalance in the proatherogenic and antiatherogenic immune networks promotes the transition of plaques from a stable to unstable state and results in the occurrence of acute coronary events.
The residual inflammatory risk (RIR) has received increasing attention in recent years, and lowering RIR has been expected to improve the outcomes of ACS patients.
The CANTOS, COLCOT, and LoDoCo trials verified the benefits of reducing cardiovascular events using anti-inflammation therapies; however, most of the other studies focusing on lowering RIR produced negative or contradicting results.
Therefore, restoring the balance in autoimmune regulation is essential because proatherogenic and antiatherogenic immunomodulatory effects are equally important in the complex human immune network.
In this review, we summarized the recent evidence of the roles of proatherogenic and antiatherogenic immune networks in the pathogenesis of ACS and discussed how immune and inflammation contribute to atherosclerosis progression, plaque instability, and adverse cardiovascular events.
We also provide a “from bench to bedside” perspective of a novel and promising personalized strategy in RIR intervention and therapeutic approaches for the treatment of ACS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Haiming& Liu, Zifan& Shao, Junjie& Lin, Lejian& Jiang, Min& Wang, Lin…[et al.]. 2020. Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Haiming…[et al.]. Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Haiming& Liu, Zifan& Shao, Junjie& Lin, Lejian& Jiang, Min& Wang, Lin…[et al.]. Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر