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Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae
المؤلفون المشاركون
Zeng, Xi
Zhang, Weijun
Zhang, Xiaoli
Yuan, Yue
Chen, Zhifu
Jing, Haiming
Zou, Jintao
Zou, Quanming
Zhang, Jinyong
Liu, Dong
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Innate immune effectors constitute the first line of host defense against pathogens.
However, the roles of these effectors are not clearly defined during Klebsiella pneumoniae (K.
pneumoniae) respiratory infection.
In the current study, we established an acute pneumonia model of K.
pneumoniae respiratory infection in mice and confirmed that the injury was most severe 48 h post infection.
Flow cytometric assay demonstrated that alveolar macrophages were the predominant cells in BALF before infection, and neutrophils were quickly recruited after infection, and this was in consistent with the kinetics of chemokine expression.
Further, we depleted neutrophils, macrophages, and complement pathways in vivo and challenged these mice with a sublethal dose of K.
pneumonia, the result showed that 80%, 60%, and 40% of mice were died in these groups, respectively, while no deaths occurred in the control group.
Besides, innate immune effector depleted mice showed higher bacterial burdens in lungs and blood, companied with more severe lung damage and increased levels of cytokine/chemokine expression.
These results demonstrated that the innate immune effectors are critical in the early controlling of K.
pneumoniae infection, and neutrophils are the most important.
Thus, alternative strategies targeting these innate immune effectors may be effective in controlling of K.
pneumoniae respiratory infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Dong& Chen, Zhifu& Yuan, Yue& Jing, Haiming& Zou, Jintao& Zhang, Xiaoli…[et al.]. 2020. Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187297
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Dong…[et al.]. Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187297
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Dong& Chen, Zhifu& Yuan, Yue& Jing, Haiming& Zou, Jintao& Zhang, Xiaoli…[et al.]. Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187297
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187297
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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