Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged by Escherichia coli
المؤلفون المشاركون
Deng, J. L.
Fang, Jing
Geng, Yi
Gu, Xuchu
Ma, Zhiyu
Cai, Dongjie
Liang, Shuang
Cui, Hengmin
Ma, Xiaoping
Zhang, Ming
Ye, Gang
Xie, Yue
Gou, Liping
Hu, Yanchun
Zuo, Z. C.
Ren, Z. H.
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Obese mice exhibited more lymphocytes in the bronchoalveolar lavage fluid and milder lung injury after Escherichia coli (E.
coli) infection.
However, it remained unclear whether the spleen contributed to the effect of obese mice with infection.
The study was purposed to reveal the histopathological changes of the spleen caused by oxidative stress and inflammation in diet-induced obesity (DIO) mice challenged by Escherichia coli.
After infection, the spleen tissues were obtained in normal and DIO mice at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection.
Results revealed that DIO mice have higher contents of resistin, TNF-α, IL-6, and IL-1β in the spleen than normal mice and lower concentrations of GSH-Px, SOD, and CAT and higher MDA than normal mice.
After an intranasal drip of E.
coli, the activities of GSH-Px, SOD, and CAT in the DIO mice were elevated and the content of MDA declined.
The activities of SOD and CAT in the normal mice declined, and the content of MDA was elevated.
Moreover, the contents of TNF-α, IL-6, and IL-1β in the spleen declined in DIO mice at 24 and 72 h, although the contents of leptin, resistin, TNF-α, IL-6, and IL-1β were elevated at 12 h.
The contents of resistin, TNF-α, IL-6, and IL-1β were elevated in normal mice at 12 and 24 h.
Those results indicated that obesity elevated splenic oxidation and inflammatory levels, but it enhanced antioxidant capacity and reduced cytokine levels of the spleen in mice to resist splenic injury after an intranasal drip of E.
coli.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gu, Xuchu& Ma, Zhiyu& Fang, Jing& Cai, Dongjie& Zuo, Z. C.& Liang, Shuang…[et al.]. 2020. Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged by Escherichia coli. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187343
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gu, Xuchu…[et al.]. Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged by Escherichia coli. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187343
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gu, Xuchu& Ma, Zhiyu& Fang, Jing& Cai, Dongjie& Zuo, Z. C.& Liang, Shuang…[et al.]. Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged by Escherichia coli. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187343
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187343
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر