Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia
المؤلفون المشاركون
Fu, Rong
Li, Lijuan
Wang, Yihao
Zhao, Yang
Shao, Qing
Wang, Yangyang
Liu, Zhaoyun
Liu, Hui
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Immune-related pancytopenia (IRP) is a kind of autoimmune disease mediated by autoantibodies in bone marrow.
T helper 9 (Th9) cell is a new subset of T cell discovered recently, which mainly expresses cytokine interleukin-9 (IL-9) to exert immune function.
Th9 cells are associated with a variety of inflammatory diseases, but the role of Th9 cells in IRP remains unclear.
Methods.
Fifty patients with IRP and 20 healthy controls were enrolled.
The percentage of Th9 cells was detected by flow cytometry (FCM) and ELISA.
CD4+ lymphocytes were sorted by magnetic beads, and the mRNA expression levels of Th9 cells related transcription factors PU.1 and BATF were detected by RT-PCR.
Results.
The percentage of Th9 cells in CD3+CD4+ cells was 2.73±1.96% in the untreated group, which was significantly higher than those in the remission group (1.21±0.86%) (p<0.01) and the control group (0.68±0.40%) (p<0.001).
And that in the remission group was significantly higher than that in the control group (p<0.05).
The level of IL-9 in the untreated group was 183.91±112.42 pg/mL, which was significantly higher than that in the remission group (105.96±64.79 pg/mL) (p<0.01) and control group (56.03±14.49 pg/mL) (p<0.001).
That in the remission group was also significantly higher than that in the control group (p<0.01).
They were negatively correlated with hemoglobin, red blood cell, white blood cell, and platelet counts and positively correlated with the percentage of CD19+B cells and CD5+CD19+/CD19+B cells, respectively.
The mRNA expression levels of PU.1 and BATF in IRP patients were higher than those in controls (p<0.05).
Conclusions.
The percentage of Th9 cells in the peripheral blood and the level of IL-9 in the serum of patients with IRP were increased, which was related to the severity of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shao, Qing& Wang, Yangyang& Liu, Zhaoyun& Liu, Hui& Wang, Yihao& Zhao, Yang…[et al.]. 2020. Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shao, Qing…[et al.]. Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia. Journal of Immunology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shao, Qing& Wang, Yangyang& Liu, Zhaoyun& Liu, Hui& Wang, Yihao& Zhao, Yang…[et al.]. Th9 Cells in Peripheral Blood Increased in Patients with Immune-Related Pancytopenia. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر