Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population
المؤلفون المشاركون
Zhang, Tian-Ping
Li, Xiaomei
Li, Rui
Huang, Qian
Pan, Han-Feng
Ye, Dong-Qing
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Recent studies have focused on the special roles of NADPH-oxidase in multiple autoimmune diseases.
Nevertheless, the association of genetic variation in NADPH-oxidase genes with rheumatoid arthritis (RA) was not extensively studied in a Chinese population.
We performed this study to examine the association of NCF2, NCF4, and CYBA gene polymorphisms with RA susceptibility in a Chinese population.
Methods.
Six single nucleotide polymorphisms (SNPs) (NCF2 rs10911363, NCF4 rs1883112, rs4821544, rs729749, CYBA rs3794624, and rs4673) were genotyped in a cohort composed of 593 RA patients and 596 normal controls.
Improved multiple ligase detection reaction (iMLDR) was used for genotyping.
Results.
We observed that NCF4 rs4821544 CT genotype and C allele frequencies in RA patients were significantly decreased when compared to controls (CT vs.
TT: P=0.043; C vs.
T: P=0.031), and rs4821544 polymorphism was significantly associated with an increased RA risk under the dominant model (TT vs.
CT+CC: P=0.031).
Our results also indicated that rs729749 CT genotype frequency was significantly lower in RA patients than that in controls (CT vs.
CC: P=0.033).
Moreover, the rs729749 CT genotype frequency was also significantly decreased in RA patients in males (CT vs.
CC: P=0.024).
No significant association between NCF2 and CYBA gene polymorphisms and RA susceptibility was observed.
There were significant associations between rs4821544 TT genotype and T allele frequencies and anti-CCP in male RA patients.
Conclusions.
In summary, NCF4 rs4821544 and rs729749 polymorphisms might contribute to RA susceptibility, while NCF2 and CYBA gene polymorphisms were not associated with RA susceptibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Tian-Ping& Li, Rui& Huang, Qian& Pan, Han-Feng& Ye, Dong-Qing& Li, Xiaomei. 2020. Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187588
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Tian-Ping…[et al.]. Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population. Journal of Immunology Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1187588
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Tian-Ping& Li, Rui& Huang, Qian& Pan, Han-Feng& Ye, Dong-Qing& Li, Xiaomei. Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1187588
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187588
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر