![](/images/graphics-bg.png)
Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis
المؤلفون المشاركون
Niu, Yu-Ming
Hu, Yuan-Yuan
Li, Xue-Feng
Huang, Zhi-Zhen
Cai, Jun-Wei
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-19
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD).
However, the published results were inconsistent.
Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility.
Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies.
Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility.
Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings.
Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included.
Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs.
T: OR=0.72, 95%CI=0.67‐0.77, P<0.01, I2=36.6%; TC vs.
TT: OR=0.73, 95%CI=0.66‐0.80, P<0.01, I2=23.0%; CC vs.
TT: OR=0.52, 95%CI=0.39‐0.70, P<0.01, I2=53.7%; TC+CC vs.
TT: OR=0.67, 95%CI=0.61‐0.71, P<0.01, I2=22.1%; and CC vs.
TT+TC: OR=0.66, 95%CI=0.53‐0.82, P<0.01, I2=57.8%).
Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility.
In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xue-Feng& Huang, Zhi-Zhen& Hu, Yuan-Yuan& Niu, Yu-Ming& Cai, Jun-Wei. 2020. Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1187682
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xue-Feng…[et al.]. Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis. Journal of Immunology Research No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1187682
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xue-Feng& Huang, Zhi-Zhen& Hu, Yuan-Yuan& Niu, Yu-Ming& Cai, Jun-Wei. Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1187682
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187682
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)