Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis
المؤلفون المشاركون
Niu, Yu-Ming
Hu, Yuan-Yuan
Li, Xue-Feng
Huang, Zhi-Zhen
Cai, Jun-Wei
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-19
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD).
However, the published results were inconsistent.
Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility.
Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies.
Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility.
Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings.
Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included.
Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs.
T: OR=0.72, 95%CI=0.67‐0.77, P<0.01, I2=36.6%; TC vs.
TT: OR=0.73, 95%CI=0.66‐0.80, P<0.01, I2=23.0%; CC vs.
TT: OR=0.52, 95%CI=0.39‐0.70, P<0.01, I2=53.7%; TC+CC vs.
TT: OR=0.67, 95%CI=0.61‐0.71, P<0.01, I2=22.1%; and CC vs.
TT+TC: OR=0.66, 95%CI=0.53‐0.82, P<0.01, I2=57.8%).
Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility.
In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xue-Feng& Huang, Zhi-Zhen& Hu, Yuan-Yuan& Niu, Yu-Ming& Cai, Jun-Wei. 2020. Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1187682
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xue-Feng…[et al.]. Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis. Journal of Immunology Research No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1187682
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xue-Feng& Huang, Zhi-Zhen& Hu, Yuan-Yuan& Niu, Yu-Ming& Cai, Jun-Wei. Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1187682
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187682
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر