Elevated IL-12, TNF-α, and TNF-αIL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion
المؤلفون المشاركون
Aninagyei, Enoch
Adu, Patrick
Egyir-Yawson, Alexander
Acheampong, Desmond Omane
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Although Plasmodium falciparum infections in blood donors have been reported, the impact of parasitaemia on cytokine levels in stored whole blood has not been explored.
This study evaluated the effect of P.
falciparum parasitaemia on circulating cytokines and their relationship with haematological parameters in banked blood.
In this case-control study, two groups of donor whole blood were recruited: P.
falciparum-infected donors (parasitaemia: 515–1877 parasites/μL) and noninfected blood donors (control).
At day 0 (baseline), 7, 14, 21, and 35 of banking circulating cytokine levels of tumor necrosis factor alpha (TNF-α), interleukin- (IL-) 12, IL-10, and IL-6 levels and haematological parameters were determined.
Kruskal-Wallis test determined differences in weekly cytokine levels while Dunn’s post hoc test determined exact significant points.
At baseline, the mean TNF-α (33.81 pg/mL vs.
22.70 pg/mL), IL-12 (28.39 pg/mL vs.
16.15 pg/mL), IL-10 (51.04 pg/mL vs.
18.95 pg/mL), and IL-6 (71.03 pg/mL vs.
30.89 pg/mL) levels were significantly higher in infected donor whole blood.
Significant rate of increase was observed in TNF-α, IL-12 levels, and TNF-α/IL-10 ratios in infected blood, while decreased levels were observed in IL-10.
IL-6 peaked at day 21 and fell below baseline level at day 35.
Significant changes in TNF-α, IL-12, IL-10, IL-6 levels, and TNF-α/IL-10 ratios in infected donor blood were observed 7 days after storage.
Unlike in noninfected stored whole blood, TNF-α, IL-6, IL-12, and TNF-α/IL-10 ratio levels in infected stored whole blood related inversely to haematological parameters (white cells, red cells, platelets, and haemoglobin levels) during storage.
However, in both groups, significant direct relationship was observed in IL-10 and haematological parameters.
In conclusion, banking of P.
falciparum-infected donor whole blood may lead to infusion of large quantities of inflammatory cytokines with potential adverse immunological response in recipients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aninagyei, Enoch& Adu, Patrick& Egyir-Yawson, Alexander& Acheampong, Desmond Omane. 2020. Elevated IL-12, TNF-α, and TNF-αIL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187685
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aninagyei, Enoch…[et al.]. Elevated IL-12, TNF-α, and TNF-αIL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion. Journal of Immunology Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1187685
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aninagyei, Enoch& Adu, Patrick& Egyir-Yawson, Alexander& Acheampong, Desmond Omane. Elevated IL-12, TNF-α, and TNF-αIL-10 Ratios in Stored Plasmodium falciparum-Infected Whole Blood: Implications for Safe Haemotransfusion. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1187685
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187685
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر