The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook
المؤلفون المشاركون
Rose, William Nicholas
Miller, Vandana
Jennings, Stephen R.
Wigdahl, Brian
Krebs, Fred C.
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-25
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Dendritic cells (DC) are key phagocytic cells that play crucial roles in both the innate and adaptive immune responses against the human immunodeficiency virus type 1 (HIV-1).
By processing and presenting pathogen-derived antigens, dendritic cells initiate a directed response against infected cells.
They activate the adaptive immune system upon recognition of pathogen-associated molecular patterns (PAMPs) on infected cells.
During the course of HIV-1 infection, a successful adaptive (cytotoxic CD8+ T-cell) response is necessary for preventing the progression and spread of infection in a variety of cells.
Dendritic cells have thus been recognized as a valuable tool in the development of immunotherapeutic approaches and vaccines effective against HIV-1.
The advancements in dendritic cell vaccines in cancers have paved the way for applications of this form of immunotherapy to HIV-1 infection.
Clinical trials with patients infected with HIV-1 who are well-suppressed by antiretroviral therapy (ART) were recently performed to assess the efficacy of DC vaccines, with the goal of mounting an HIV-1 antigen-specific T-cell response, ideally to clear infection and eliminate the need for long-term ART.
This review summarizes and compares methods and efficacies of a number of DC vaccine trials utilizing autologous dendritic cells loaded with HIV-1 antigens.
The potential for advancement and novel strategies of improving efficacy of this type of immunotherapy is also discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rose, William Nicholas& Miller, Vandana& Jennings, Stephen R.& Wigdahl, Brian& Krebs, Fred C.. 2020. The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1187693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rose, William Nicholas…[et al.]. The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook. Journal of Immunology Research No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1187693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rose, William Nicholas& Miller, Vandana& Jennings, Stephen R.& Wigdahl, Brian& Krebs, Fred C.. The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1187693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر