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Dendritic Cells Transfected with MHC Antigenic Determinants of CBA Mice Induce Antigen-Specific Tolerance in C57Bl6 Mice
المؤلفون المشاركون
Sennikov, Sergey V.
Silkov, Alexander N.
Kurilin, Vasiliy V.
Khantakova, Julia N.
Tereshchenko, Valeriy P.
Shevchenko, Julia A.
Lopatnikova, Julia A.
Maksyutov, Amir Z.
Kuznetsova, Maria S.
Knauer, Nadezda Y.
Bulygin, Aleksey S.
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Nonspecific immunosuppressive therapy for graft rejection and graft-versus-host disease (GVHD) is often accompanied by severe side effects such as opportunistic infections and cancers.
Several approaches have been developed to suppress transplantation reactions using tolerogenic cells, including induction of FoxP3+ Tregs with antigen-loaded dendritic cells (DCs) and induction of CD4+IL-10+ cells with interleukin IL-10-producing DCs.
Here, we assessed the effectiveness of both approaches in the suppression of graft rejection and GVHD.
Methods.
IL-10-producing DCs were generated by the transfection of DCs with DNA constructs encoding mouse IL-10.
Antigen-loaded DCs from C57BL/6 mice were generated by transfection with DNA constructs encoding antigenic determinants from the H2 locus of CBA mice which differ from the homologous antigenic determinants of C57BL/6 mice.
Results.
We found that both IL-10-producing DCs and antigen-loaded immature DCs could suppress graft rejection and GVHD but through distinct nonspecific and antigen-specific mechanisms, respectively.
Discussion.
We provide data that the novel approach for DCs antigen loading using DNA constructs encoding distinct homologous determinants derived from major histocompatibility complex genes is effective in antigen-specific suppression of transplantation reactions.
Such an approach eliminates the necessity of donor material use and may be useful in immunosuppressive therapy side effects prevention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sennikov, Sergey V.& Tereshchenko, Valeriy P.& Kurilin, Vasiliy V.& Shevchenko, Julia A.& Lopatnikova, Julia A.& Silkov, Alexander N.…[et al.]. 2020. Dendritic Cells Transfected with MHC Antigenic Determinants of CBA Mice Induce Antigen-Specific Tolerance in C57Bl6 Mice. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187723
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sennikov, Sergey V.…[et al.]. Dendritic Cells Transfected with MHC Antigenic Determinants of CBA Mice Induce Antigen-Specific Tolerance in C57Bl6 Mice. Journal of Immunology Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1187723
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sennikov, Sergey V.& Tereshchenko, Valeriy P.& Kurilin, Vasiliy V.& Shevchenko, Julia A.& Lopatnikova, Julia A.& Silkov, Alexander N.…[et al.]. Dendritic Cells Transfected with MHC Antigenic Determinants of CBA Mice Induce Antigen-Specific Tolerance in C57Bl6 Mice. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1187723
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187723
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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