A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma
المؤلفون المشاركون
Kaye, James A.
Odom, Dawn
Mladsi, Deirdre
Purser, Molly
Palaka, Eirini
Charter, Alina
Jensen, Jo Annah
Sellami, Dalila
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy.
Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE).
We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparison (MAIC) versus an unadjusted indirect comparison.
Methods.
After comparing trials and identifying potential prognostic factors, an MAIC was conducted to adjust for differences in key patient baseline characteristics.
Due to BOLT’s small sample size, the number of matching variables was restricted to two.
Efficacy results for sonidegib were generated so that selected baseline characteristics matched those from ERIVANCE and were compared with published ERIVANCE results.
Results.
Matching variables were baseline percentages of patients receiving prior radiotherapy and surgery.
After weighting, sonidegib objective response rate (ORR) and median progression-free survival (PFS) were effectively unchanged (prematched versus postmatched ORR and PFS, 56.1% versus 56.7% and 22.1 versus 22.1 months, resp.).
Vismodegib’s ORR and PFS were 47.6% and 9.5 months.
Conclusions.
Comparative effectiveness of sonidegib versus vismodegib remains unchanged after adjusting BOLT patient-level data to match published ERIVANCE baseline percentages of patients receiving prior surgery and radiotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Odom, Dawn& Mladsi, Deirdre& Purser, Molly& Kaye, James A.& Palaka, Eirini& Charter, Alina…[et al.]. 2017. A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma. Journal of Skin Cancer،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1187739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Odom, Dawn…[et al.]. A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma. Journal of Skin Cancer No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1187739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Odom, Dawn& Mladsi, Deirdre& Purser, Molly& Kaye, James A.& Palaka, Eirini& Charter, Alina…[et al.]. A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma. Journal of Skin Cancer. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1187739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر