Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines
المؤلفون المشاركون
Roggo, Y.
Dégardin, Klara
Guillemain, Aurélie
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The fight against medicine counterfeiting is a current focus of the pharmaceutical world.
Reliable analytical tools are needed to pursue the counterfeiters.
Handheld devices present the advantage of providing quick results, with analyses possibly performed on the field.
A large number of solid-dosage form medicines have been analyzed with a handheld Raman spectrometer.
33 out of 39 product families could be successfully analysed.
The methods were validated with 100% of correct identification.
Each product was additionally tested by the methods of the other products and successfully rejected.
A second validation was performed using counterfeits, placebos, and generics.
All the counterfeits were rejected, with p values close to zero.
Some generics presented a similar formulation to the brand products and were then identified as such.
One placebo was positively identified, showing that low dosage products are difficult to analyze with Raman.
Robustness tests were carried out, showing, for instance, that the operator has no influence on the results and that the analyses might be performed through transparent packaging.
The discovery mode was also investigated, which proposes the chemical composition of the samples.
The results demonstrated that the Raman handheld device is a reliable tool for the field analysis of counterfeits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dégardin, Klara& Guillemain, Aurélie& Roggo, Y.. 2017. Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines. Journal of Spectroscopy،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1187800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dégardin, Klara…[et al.]. Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines. Journal of Spectroscopy No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1187800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dégardin, Klara& Guillemain, Aurélie& Roggo, Y.. Comprehensive Study of a Handheld Raman Spectrometer for the Analysis of Counterfeits of Solid-Dosage Form Medicines. Journal of Spectroscopy. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1187800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر