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Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microcirculatory Resistance Registry Data
المؤلفون المشاركون
Jang, Ji-Hun
Lee, Man-Jong
Ko, Kyu-Yong
Park, Jin-Hee
Baek, Yong-Soo
Sung-Woo, Kwon
Shin, Sung-Hee
Woo, Seong-Ill
Kim, Dae-Hyeok
Suh, Young Ju
Kwan, Jun
Park, Sang-Don
المصدر
Journal of Interventional Cardiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objectives.
We aimed to identify mechanical and pharmacological revascularization strategies correlated with the index of microcirculatory resistance (IMR) in ST-elevation myocardial infarction (STEMI) patients.
Background.
Microvascular dysfunction (MVD) after STEMI is correlated with infarct size and poor long-term prognosis, and the IMR is a useful analytical method for the quantitative assessment of MVD.
However, therapeutic strategies that can reliably reduce MVD remain uncertain.
Methods.
Patients with STEMI who underwent primary percutaneous coronary intervention (PCI) were enrolled.
The IMR was measured with a pressure sensor/thermistor-tipped guidewire immediately after primary PCI.
High IMR was defined as values ≥66th percentile of IMR in enrolled patients (IMR > 30.9 IU).
Results.
A total of 160 STEMI patients were analyzed (high IMR = 54 patients).
Clinical factors for Killip class P=0.006, delayed hospitalization from symptom onset P=0.004, peak troponin-I level P=0.042, and multivessel disease P=0.003 were associated with high IMR.
Achieving final thrombolysis in myocardial infarction myocardial perfusion grade 3 tended to be associated with low IMR P=0.119, whereas the presence of distal embolization was significantly associated with high IMR P=0.034.
In terms of therapeutic strategies that involved adjusting clinical and angiographic factors associated with IMR, preloading of third-generation P2Y12 inhibitors correlated with reducing IMR value (β = −10.30, P<0.001).
Mechanical therapeutic strategies including stent diameter/length, preballoon dilatation, direct stenting, and thrombectomy were not associated with low IMR value (all P>0.05), and postballoon dilatation was associated with high IMR (β = 8.30, P=0.020).
Conclusions.
In our study, mechanical strategies were suboptimal in achieving myocardial salvage.
Preloading of third-generation P2Y12 inhibitors revealed decreased IMR value, indicative of MVD prevention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Ji-Hun& Lee, Man-Jong& Ko, Kyu-Yong& Park, Jin-Hee& Baek, Yong-Soo& Sung-Woo, Kwon…[et al.]. 2020. Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microcirculatory Resistance Registry Data. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187815
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Ji-Hun…[et al.]. Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microcirculatory Resistance Registry Data. Journal of Interventional Cardiology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1187815
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Ji-Hun& Lee, Man-Jong& Ko, Kyu-Yong& Park, Jin-Hee& Baek, Yong-Soo& Sung-Woo, Kwon…[et al.]. Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microcirculatory Resistance Registry Data. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1187815
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187815
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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