Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry
المؤلفون المشاركون
Muntean, Dana Maria
Alecu, Cristian
Tomuta, Ioan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Near-infrared spectroscopy (NIRS) is a technique widely used for rapid and nondestructive analysis of solid samples.
A method for simultaneous analysis of the two components of paracetamol and caffeine from powder blends has been developed by using chemometry with near-infrared spectroscopy (NIRS).
The method development was performed on samples containing 80, 90, 100, 110, and 120% active pharmaceutical ingredients, and near-infrared spectroscopy (NIRS) spectra of prepared powder blends were recorded and analyzed in order to develop models for the prediction of drug content.
Many calibration models were applied in order to perform quantitative determination of drug content in powder, and choosing the appropriate number of factors (principal components) proved to be of highly importance for a PLS chemometric calibration.
Once the methods were developed, they were validated in terms of trueness, precision, and accuracy.
The results obtained by NIRS methods were compared with those obtained by HPLC reference method, and no significant differences were found.
Therefore, the NIR chemometry methods were proved to be a suitable tool for predicting chemical properties of powder blends and for simultaneous determination of active pharmaceutical ingredients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muntean, Dana Maria& Alecu, Cristian& Tomuta, Ioan. 2017. Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry. Journal of Spectroscopy،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1187852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muntean, Dana Maria…[et al.]. Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry. Journal of Spectroscopy No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1187852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muntean, Dana Maria& Alecu, Cristian& Tomuta, Ioan. Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry. Journal of Spectroscopy. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1187852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر