Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia
المؤلفون المشاركون
Siller-López, Fernando
Garzón-Castaño, Sandra
Ramos-Márquez, Martha E.
Hernández-Cañaveral, Iván
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, hydrolyzes several organophosphate pesticides and oxidized lipids.
The PON1 Q192R polymorphism affects the catalytic efficiency and is considered a risk factor for pesticide intoxication and cardiovascular disease (CVD) but the association is not consistent between individuals or populations.
We aimed to study the association of PON1 Q192R polymorphism with CVD risk in coffee harvesters of central Colombia.
Demographics were collected from 205 subjects via standardized questionnaires.
Lipid profiles and serum butyrylcholinesterase (BChE) were measured by standard procedures.
The calculated 10-year atherosclerotic CVD (ASCVD) risk was used as the cardiovascular risk estimate.
Q192R genotype was determined by real-time PCR.
Prevalence of hypertension, hypercholesterolemia, and the 10-year ASCVD risk was 33%, 62%, and 22%, respectively.
BChE levels were no indicative of recent pesticide exposure, although a positive correlation was observed with BChE and hypercholesterolemia.
The Q192R genotype frequencies were 38% (QQ), 44% (QR), and 18% (RR).
We found an association of the 192Q genotype with hypertension.
The results of this study signal the importance to evaluate the influence and potential interactions of BChE and PON1 192Q allele with known genetic and environmental factors implicated in the pathogenesis of CVD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siller-López, Fernando& Garzón-Castaño, Sandra& Ramos-Márquez, Martha E.& Hernández-Cañaveral, Iván. 2017. Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia. Journal of Toxicology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1187906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siller-López, Fernando…[et al.]. Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia. Journal of Toxicology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1187906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siller-López, Fernando& Garzón-Castaño, Sandra& Ramos-Márquez, Martha E.& Hernández-Cañaveral, Iván. Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia. Journal of Toxicology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1187906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر