Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule
المؤلفون المشاركون
Jawi, Motasim M.
Frohlich, Jiri
Chan, Sammy Y.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-26، 26ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-01
دولة النشر
مصر
عدد الصفحات
26
التخصصات الرئيسية
الملخص EN
Lipoprotein(a) [Lp(a)], aka “Lp little a”, was discovered in the 1960s in the lab of the Norwegian physician Kåre Berg.
Since then, we have greatly improved our knowledge of lipids and cardiovascular disease (CVD).
Lp(a) is an enigmatic class of lipoprotein that is exclusively formed in the liver and comprises two main components, a single copy of apolipoprotein (apo) B-100 (apo-B100) tethered to a single copy of a protein denoted as apolipoprotein(a) apo(a).
Plasma levels of Lp(a) increase soon after birth to a steady concentration within a few months of life.
In adults, Lp(a) levels range widely from <2 to 2500 mg/L.
Evidence that elevated Lp(a) levels >300 mg/L contribute to CVD is significant.
The improvement of isoform-independent assays, together with the insight from epidemiologic studies, meta-analyses, genome-wide association studies, and Mendelian randomization studies, has established Lp(a) as the single most common independent genetically inherited causal risk factor for CVD.
This breakthrough elevated Lp(a) from a biomarker of atherosclerotic risk to a target of therapy.
With the emergence of promising second-generation antisense therapy, we hope that we can answer the question of whether Lp(a) is ready for prime-time clinic use.
In this review, we present an update on the metabolism, pathophysiology, and current/future medical interventions for high levels of Lp(a).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jawi, Motasim M.& Frohlich, Jiri& Chan, Sammy Y.. 2020. Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule. Journal of Lipids،Vol. 2020, no. 2020, pp.1-26.
https://search.emarefa.net/detail/BIM-1187918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jawi, Motasim M.…[et al.]. Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule. Journal of Lipids No. 2020 (2020), pp.1-26.
https://search.emarefa.net/detail/BIM-1187918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jawi, Motasim M.& Frohlich, Jiri& Chan, Sammy Y.. Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule. Journal of Lipids. 2020. Vol. 2020, no. 2020, pp.1-26.
https://search.emarefa.net/detail/BIM-1187918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر