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Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored
المؤلفون المشاركون
González, Fernando
López, René
Arriagada, Elizabeth
Carrasco, René
Gallardo, Natalia
Lorca, Eduardo
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients.
Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch.
Methods.
Forty-one stable Prograf (Astellas) receiving kidney transplant patients were switched to a generic tacrolimus (Sandoz) in a 1 : 1 dose ratio and were followed up for up to 8 months.
All other drugs were maintained as per normal practice.
Results.
Neither tacrolimus doses nor their trough blood levels changed significantly after the switch, but serum creatinine did: 1.62±0.90 versus 1.75±0.92 mg/dL (p<0.001).
At the same time, five graft biopsies were performed, and two of them showed cellular acute rejection.
There were nine infectious episodes treated satisfactorily with proper therapies.
No patient or graft was lost during the follow-up time period.
Conclusion.
Switching from brand name tacrolimus to a generic tacrolimus (Sandoz) is feasible and appears to be safe, but it must be monitored carefully by treating physicians.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
González, Fernando& López, René& Arriagada, Elizabeth& Carrasco, René& Gallardo, Natalia& Lorca, Eduardo. 2017. Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored. Journal of Transplantation،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1187988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
González, Fernando…[et al.]. Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored. Journal of Transplantation No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1187988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
González, Fernando& López, René& Arriagada, Elizabeth& Carrasco, René& Gallardo, Natalia& Lorca, Eduardo. Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored. Journal of Transplantation. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1187988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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