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Blood Transfusions and Tumor Biopsy May Increase HCC Recurrence Rates after Liver Transplantation
المؤلفون المشاركون
Pratschke, Johann
Seehofer, Daniel
Öllinger, Robert
Denecke, Timm
Schmelzle, Moritz
Schott, Eckart
Andreou, Andreas
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Beneath tumor grading and vascular invasion, nontumor related risk factors for HCC recurrence after liver transplantation (LT) have been postulated.
Potential factors were analyzed in a large single center experience.
Material and Methods.
This retrospective analysis included 336 consecutive patients transplanted for HCC.
The following factors were analyzed stratified for vascular invasion: immunosuppression, rejection therapy, underlying liver disease, age, gender, blood transfusions, tumor biopsy, caval replacement, waiting time, Child Pugh status, and postoperative complications.
Variables with a potential prognostic impact were included in a multivariate analysis.
Results.
The 5- and 10-year patient survival rates were 70 and 54%.
The overall 5-year recurrence rate was 48% with vascular invasion compared to 10% without (p<0.001).
Univariate analysis stratified for vascular invasion revealed age over 60, pretransplant tumor biopsy, and the application of blood transfusions as significant risk factors for tumor recurrence.
Blood transfusions remained the only significant risk factor in the multivariate analysis.
Recurrence occurred earlier and more frequently in correlation with the number of applied transfusions.
Conclusion.
Tumor related risk factors are most important and can be influenced by patient selection.
However, it might be helpful to consider nontumor related risk factors, identified in the present study for further optimization of the perioperative management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seehofer, Daniel& Öllinger, Robert& Denecke, Timm& Schmelzle, Moritz& Andreou, Andreas& Schott, Eckart…[et al.]. 2017. Blood Transfusions and Tumor Biopsy May Increase HCC Recurrence Rates after Liver Transplantation. Journal of Transplantation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seehofer, Daniel…[et al.]. Blood Transfusions and Tumor Biopsy May Increase HCC Recurrence Rates after Liver Transplantation. Journal of Transplantation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1187997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seehofer, Daniel& Öllinger, Robert& Denecke, Timm& Schmelzle, Moritz& Andreou, Andreas& Schott, Eckart…[et al.]. Blood Transfusions and Tumor Biopsy May Increase HCC Recurrence Rates after Liver Transplantation. Journal of Transplantation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187997
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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