CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis
المؤلفون المشاركون
Crooks, James
Gargaro, Marco
Vacca, Carmine
Volpi, Claudia
Pirro, Matteo
Scalisi, Giulia
Turco, Antonella
Romani, Rita
Matino, Davide
Rostami, Abdolmohamad
Gran, Bruno
Fallarino, Francesca
Puccetti, P.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory, demyelinating disease of the CNS that mimics human multiple sclerosis (MS), and it is thought to be driven by Th1 and Th17 myelin-reactive cells.
Although adaptive immunity is clearly pivotal in the pathogenesis of EAE, with an essential role of CD4+ T cells, little is known of early, innate responses in this experimental setting.
CpG-rich oligodeoxynucleotides (ODNs), typically found in microbial genomes, are potent activators of TLR9 in plasmacytoid dendritic cells (pDCs).
In this study, we compared the effects of two types of CpG, namely, type A and type B, on EAE.
We found that treatment with CpG type A ODN (CpG-A), known to induce high amounts of IFN-α in pDCs, significantly reduced disease severity in EAE, relative to controls (12.63±1.86 versus 23.49±1.46, resp.; p=0.001).
Treatment also delayed onset of neurological deficits and reduced spinal cord demyelination, while increasing the percentage of splenic regulatory (Foxp3+ CD4+) T cells.
CpG-A likewise reduced the levels of IL-17 and IFN-γ in the CNS.
Mechanistic insight into those events showed that CpG-A promoted a regulatory phenotype in pDCs.
Moreover, adoptive transfer of pDCs isolated from CpG-A-treated mice inhibited CNS inflammation and induced disease remission in acute-phase EAE.
Our data thus identify a link between TLR9 activation by specific ligands and the induction of tolerance via innate immunity mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Crooks, James& Gargaro, Marco& Vacca, Carmine& Volpi, Claudia& Pirro, Matteo& Scalisi, Giulia…[et al.]. 2017. CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188068
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Crooks, James…[et al.]. CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188068
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Crooks, James& Gargaro, Marco& Vacca, Carmine& Volpi, Claudia& Pirro, Matteo& Scalisi, Giulia…[et al.]. CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188068
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188068
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر