Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model
المؤلفون المشاركون
Ni, Shunlan
Li, Shanshan
Yang, Naibin
Tang, Xinyue
Zhang, Shengguo
Hu, Danping
Lu, Mingqin
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aims.
Acute-on-chronic liver failure (ACLF) and acute liver failure (ALF) are similar in many respects during their acute exacerbation; however, ACLF generally has a poorer prognosis.
We aimed to investigate the role and dynamic changes of regulatory T cell (Treg) and T helper 17 (Th17) cell proportions during ACLF progress.
Methods.
All rats were classified into two groups randomly: ACLF group and ALF group (control group).
The rat model of ACLF was preestablished by intraperitoneal injection of carbon tetrachloride for 2 months.
Then acute liver injury was induced by combined D-galactosamine and lipopolysaccharide.
Six time points were examined before or after acute induction.
Liver samples were performed with hematoxylin-eosin and Masson staining; circulatory Treg and Th17 cell frequencies were determined using flow cytometry assays; serum levels of alanine aminotransferase, aspartate aminotransferase, interleukin-10 (IL-10), and interferon-γ (IFN-γ) were examined.
Results.
In group ACLF, both Th17 cell proportion and IFN-γ level presented upgrade firstly and then descend latter tendency; the trends of Treg cell proportion and IL-10 level were observed to gradually decrease and became stable.
Conclusion.
The Treg cells played an important role in the immunologic mechanism during the process of ACLF.
And the function of Treg cells in ACLF was defective.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ni, Shunlan& Li, Shanshan& Yang, Naibin& Tang, Xinyue& Zhang, Shengguo& Hu, Danping…[et al.]. 2017. Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ni, Shunlan…[et al.]. Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ni, Shunlan& Li, Shanshan& Yang, Naibin& Tang, Xinyue& Zhang, Shengguo& Hu, Danping…[et al.]. Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر