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IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes
المؤلفون المشاركون
Li, Xia
Wang, Bing
Li, Fang
Li, Ming
Ma, Zijian
Wang, Miaomiao
Sun, Xiaotong
Tang, Yawei
Zhang, Yan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a chronic autoimmune disease which is characterized by synovial inflammation and cartilage damage for which causes articular dysfunction.
Activation of fibroblast-like synoviocytes (FLS) is a critical step that promotes disease progression.
In this study, we aimed to explore the effect of interleukin-34 (IL-34) on RA FLS as a proinflammatory factor and IL-34-stimulated FLS on the production of Th17.
We found that serum IL-34 levels were increased compared to those of the healthy controls and had positive correlations with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anticyclic citrullinated peptide (CCP) antibody accordingly.
CSF-1R was also highly expressed on RA FLS.
The interaction of IL-34 and CSF-1R promoted a dramatic production of IL-6 by FLS through JNK/P38/NF-κB signaling pathway.
Further, the IL-34-stimulated IL-6 secretion by RA FLS was found to upregulate the number of Th17.
The treatment of IL-6R antagonist could attenuate the production of Th17 mediated by IL-34-stimulated RA FLS.
Our results suggest that the increased IL-34 levels were closely related to the disease activity of RA.
Additionally, the overexpression of IL-6 in the IL-34-stimulated FLS promoted the generation of Th17.
Therefore, IL-34 was supposed to be involved in the pathogenesis of RA.
The inhibition of IL-34 might provide a novel target for therapies of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Bing& Ma, Zijian& Wang, Miaomiao& Sun, Xiaotong& Tang, Yawei& Li, Ming…[et al.]. 2017. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Bing…[et al.]. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Bing& Ma, Zijian& Wang, Miaomiao& Sun, Xiaotong& Tang, Yawei& Li, Ming…[et al.]. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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