Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats
المؤلفون المشاركون
Pang, Honggang
Huang, Tinqin
Song, Jinning
Zhao, Yonglin
Ma, Xudong
Zhao, Yahui
Zhang, Ming
Li, Jiaxi
Zhao, Junjie
Wang, Bo
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Treatment of diffuse axonal injury (DAI) remains challenging in clinical practice due to the unclear pathophysiological mechanism.
Uncontrolled, excessive inflammation is one of the most recognized mechanisms that contribute to the secondary injury after DAI.
Toll like receptor 2 (TLR2) is highlighted for the initiation of a vicious self-propagating inflammatory circle.
However, the role and detailed mechanism of TLR2 in secondary injury is yet mostly unknown.
In this study, we demonstrated the expression of TLR2 levels in cortex, corpus callosum, and internal capsule and the localization of TLR2 in neurons and glial cells in rat DAI models.
Intracerebral knockdown of TLR2 significantly downregulated TLR2 expression, attenuated cortical apoptosis, lessened glial response, and reduced the secondary axonal and neuronal injury in the cortex by inhibiting phosphorylation of mitogen-activated protein kinases (MAPK) including Erk, JNK, and p38, translocation of NF-κB p65 from the cytoplasm to the nucleus, and decreasing levels of proinflammatory cytokines including interleukin-6, interleukin-1β, and tumor necrosis factor-α.
On the contrary, administration of TLR2 agonist to DAI rats achieved an opposite effect.
Collectively, we demonstrated that TLR2 was involved in mediating secondary injury after DAI by inducing inflammation via the MAPK and NF-κB pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Yonglin& Zhao, Junjie& Zhang, Ming& Zhao, Yahui& Li, Jiaxi& Ma, Xudong…[et al.]. 2017. Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1188093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Yonglin…[et al.]. Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. Mediators of Inflammation No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1188093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Yonglin& Zhao, Junjie& Zhang, Ming& Zhao, Yahui& Li, Jiaxi& Ma, Xudong…[et al.]. Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1188093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر