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Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma
المؤلفون المشاركون
Gangemi, Sebastiano
Pioggia, Giovanni
Allegra, Alessandro
Innao, Vanessa
Allegra, Andrea Gaetano
Musolino, Caterina
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-26
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Multiple myeloma (MM) is typically exemplified by a desynchronized cytokine system with increased levels of inflammatory cytokines.
We focused on the contrast between inflammatory and anti-inflammatory systems by assessing the role of cytokines and their influence on MM.
The aim of this review is to summarize the available information to date concerning this equilibrium to provide an overview of the research exploring the roles of serum cytokines in MM.
However, the association between MM and inflammatory cytokines appears to be inadequate, and other functions, such as pro-proliferative or antiproliferative effects, can assume the role of cytokines in the genesis and progression of MM.
It is possible that inflammation, when guided by cancer-specific Th1 cells, may inhibit tumour onset and progression.
In a Th1 microenvironment, proinflammatory cytokines (e.g., IL-6 and IL-1) may contribute to tumour eradication by attracting leucocytes from the circulation and by increasing CD4 + T cell activity.
Hence, caution should be used when considering therapies that target factors with pro- or anti-inflammatory activity.
Drugs that may reduce the tumour-suppressive Th1-driven inflammatory immune response should be avoided.
A better understanding of the relationship between inflammation and myeloma will ensure more effective therapeutic interventions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Musolino, Caterina& Allegra, Alessandro& Innao, Vanessa& Allegra, Andrea Gaetano& Pioggia, Giovanni& Gangemi, Sebastiano. 2017. Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-24.
https://search.emarefa.net/detail/BIM-1188126
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Musolino, Caterina…[et al.]. Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma. Mediators of Inflammation No. 2017 (2017), pp.1-24.
https://search.emarefa.net/detail/BIM-1188126
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Musolino, Caterina& Allegra, Alessandro& Innao, Vanessa& Allegra, Andrea Gaetano& Pioggia, Giovanni& Gangemi, Sebastiano. Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-24.
https://search.emarefa.net/detail/BIM-1188126
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188126
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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