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Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products
المؤلفون المشاركون
Monteiro, Ana Paula T.
Pinheiro, Carla da S.
Dutra, Fabiano F.
Peters-Golden, Marc
Benjamim, Claudia F.
Canetti, Cláudio
Bozza, Marcelo T.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses.
Among them, phagocytosis is a critical process for host defense.
Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis.
Here, we evaluated the participation of TLR2, TLR3, TLR4, and TLR9 in FcγR-mediated phagocytosis and whether this process is modulated by LTs.
Rat alveolar macrophages (AMs), murine bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PMs) treated with TLR2, TLR3, and TLR4 agonists, but not TLR9, enhanced IgG-opsonized sheep red blood cell (IgG-sRBC) phagocytosis.
Pretreatment of AMs or BMDMs with drugs that block LT synthesis impaired the phagocytosis promoted by TLR ligands, and TLR potentiation was also abrogated in PMs and BMDMs from 5-LO−/− mice.
LTB4 production induced by IgG engagement was amplified by TLR ligands, while cys-LTs were amplified by activation of TLR2 and TLR4, but not by TLR3.
We also noted higher ERK1/2 phosphorylation in IgG-RBC-challenged cells when preincubated with TLR agonists.
Furthermore, ERK1/2 inhibition by PD98059 reduced the phagocytic activity evoked by TLR agonists.
Together, these data indicate that TLR2, TLR3, and TLR4 ligands, but not TLR9, amplify IgG-mediated phagocytosis by a mechanism which requires LT production and ERK-1/2 pathway activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pinheiro, Carla da S.& Monteiro, Ana Paula T.& Dutra, Fabiano F.& Bozza, Marcelo T.& Peters-Golden, Marc& Benjamim, Claudia F.…[et al.]. 2017. Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pinheiro, Carla da S.…[et al.]. Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pinheiro, Carla da S.& Monteiro, Ana Paula T.& Dutra, Fabiano F.& Bozza, Marcelo T.& Peters-Golden, Marc& Benjamim, Claudia F.…[et al.]. Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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