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IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite
المؤلفون المشاركون
Kim, Dae Woo
Kim, Dong-Kyu
Eun, Kyoung Mi
Bae, Jun-Sang
Chung, Young-Jun
Xu, Jun
Kim, Yong Min
Mo, Ji-Hun
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Purpose.
When house dust mite (HDM), a common allergen, comes into the mucosal membrane, it may stimulate innate immunity.
However, the precise role of interleukin- (IL-) 25 in the development of HDM-induced nasal allergic inflammation is still unclear.
Therefore, we investigated the role of IL-25 in allergic rhinitis (AR) patients sensitized to HDM.
Methods.
To confirm the production of IL-25 in human nasal epithelial cells (HNECs), we stimulated HNECs.
IL-25 expression in the nasal mucosa from control, non-AR (NAR) patients, and HDM-sensitized AR patients was assessed using immunohistochemistry, and quantitative reverse transcription PCR.
Correlations between IL-25 and other inflammatory markers were explored.
Results.
An in vitro study showed significantly elevated concentrations of IL-25 in the HNEC samples with highest doses of HDM.
Nasal tissues from AR patients sensitized to HDM showed significantly higher IL-25 expression, compared to those from the control or NAR patients.
Moreover, the expression of IL-25 in nasal tissues from AR patients sensitized to HDM was positively associated with Th2 markers, such as ECP and GATA3.
Conclusions.
IL-25 expression increased with high-dose HDM stimulation and was related to Th2 markers.
Therefore, IL-25 neutralization might offer a new strategy for treating patients with HDM-sensitized AR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Dae Woo& Kim, Dong-Kyu& Eun, Kyoung Mi& Bae, Jun-Sang& Chung, Young-Jun& Xu, Jun…[et al.]. 2017. IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188306
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Dae Woo…[et al.]. IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188306
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Dae Woo& Kim, Dong-Kyu& Eun, Kyoung Mi& Bae, Jun-Sang& Chung, Young-Jun& Xu, Jun…[et al.]. IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188306
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188306
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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