Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer
المؤلفون المشاركون
Morrow, Riley J.
Etemadi, Nima
Yeo, Belinda
Ernst, Matthias
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-21
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Inflammatory breast cancer is a rare, yet highly aggressive form of breast cancer, which accounts for less than 5% of all locally advanced presentations.
The clinical presentation of inflammatory breast cancer often differs significantly from that of noninflammatory breast cancer; however, immunohistochemistry reveals few, if any, distinguishing features.
The more aggressive triple-negative and HER2-positive breast cancer subtypes are overrepresented in inflammatory breast cancer compared with noninflammatory breast cancer, with a poorer prognosis in response to conventional therapies.
Despite its name, there remains some controversy regarding the role of inflammation in inflammatory breast cancer.
This review summarises the current molecular evidence suggesting that inflammatory signaling pathways are upregulated in this disease, including NF-κB activation and excessive IL-6 production among others, which may provide an avenue for novel therapeutics.
The role of the tumor microenvironment, through tumor-associated macrophages, infiltrating lymphocytes, and cancer stem cells is also discussed, suggesting that these tumor extrinsic factors may help account for the differences in behavior between inflammatory breast cancer and noninflammatory breast cancer.
While there are various novel treatment strategies already underway in clinical trials, the need for further development of preclinical models of this rare but aggressive disease is paramount.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morrow, Riley J.& Etemadi, Nima& Yeo, Belinda& Ernst, Matthias. 2017. Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1188337
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morrow, Riley J.…[et al.]. Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer. Mediators of Inflammation No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1188337
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morrow, Riley J.& Etemadi, Nima& Yeo, Belinda& Ernst, Matthias. Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1188337
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188337
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر