The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
المؤلفون المشاركون
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Inflammation is part of our body’s response to tissue injury and pathogens.
It helps to recruit various immune cells to the site of inflammation and activates the production of mediators to mobilize systemic protective processes.
However, chronic inflammation can increase the risk of diseases like cancer.
Apart from cytokines and chemokines, lipid mediators, particularly sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P), contribute to inflammation and cancer.
S1P is an important player in inflammation-associated colon cancer progression.
On the other hand, C1P has been recognized to be involved in cancer cell growth, migration, survival, and inflammation.
However, whether C1P is involved in inflammation-associated cancer is not yet established.
In contrast, few studies have also suggested that S1P and C1P are involved in anti-inflammatory pathways regulated in certain cell types.
Ceramide is the substrate for ceramide kinase (CERK) to yield C1P, and sphingosine is phosphorylated to S1P by sphingosine kinases (SphKs).
Biological functions of sphingolipid metabolites have been studied extensively.
Ceramide is associated with cell growth inhibition and enhancement of apoptosis while S1P and C1P are associated with enhancement of cell growth and survival.
Altogether, S1P and C1P are important regulators of ceramide level and cell fate.
This review focuses on S1P and C1P involvement in inflammation and cancer with emphasis on recent progress in the field.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hait, Nitai C.& Maiti, Aparna. 2017. The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1188350
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hait, Nitai C.& Maiti, Aparna. The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer. Mediators of Inflammation No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1188350
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hait, Nitai C.& Maiti, Aparna. The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1188350
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188350
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر