Characterization and Application of Carboxymethyl Chitosan-Based Bioink in Cartilage Tissue Engineering
المؤلفون المشاركون
He, Yunfan
Lu, Feng
Derakhshanfar, Soroosh
Zhong, Wen
Li, Bingyun
Xing, Malcolm
Li, Xiaojian
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chitosan is a promising natural biomaterial for biological application; however, the weak mechanical performance of pristine chitosan limits its further utilization in hard tissue (such as cartilage) engineering.
In this study, a chitosan-based 3D printing bioink with suitable mechanical properties was developed as 3D bioprinting ink for chondrocyte support.
Chitosan was first modified by ethylenediaminetetraacetic acid (EDTA) to provide more carboxyl groups followed by physical crosslinking with calcium to increase the hydrogel strength.
Dynamic mechanical analysis was carried out to evaluate viscoelastic properties with the addition of modified chitosan.
A bioink with a combination of modified and pristine chitosan was formulated for scaffold fabrication via 3D bioprinting technique.
Furthermore, cell viability, cell proliferation, and expression of chondrogenic markers were evaluated in vitro in chondrocytes loaded on the bioink.
The novel bioink exhibited a favorable mechanical property and promoted cell attachment and chondrogenic gene expression in chondrocytes.
Based on these results, we can conclude that the presented bioink could qualify for use in 3D bioprinting in cartilage tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Yunfan& Derakhshanfar, Soroosh& Zhong, Wen& Li, Bingyun& Lu, Feng& Xing, Malcolm…[et al.]. 2020. Characterization and Application of Carboxymethyl Chitosan-Based Bioink in Cartilage Tissue Engineering. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Yunfan…[et al.]. Characterization and Application of Carboxymethyl Chitosan-Based Bioink in Cartilage Tissue Engineering. Journal of Nanomaterials No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1188366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Yunfan& Derakhshanfar, Soroosh& Zhong, Wen& Li, Bingyun& Lu, Feng& Xing, Malcolm…[et al.]. Characterization and Application of Carboxymethyl Chitosan-Based Bioink in Cartilage Tissue Engineering. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر