Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia
المؤلفون المشاركون
Hou, Yu-Chen
Shih, Yao-Ming
Shih, Juey-Ming
Yeh, Chiu-Li
Li, Cheng-Che
Yeh, Sung-Ling
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study investigated the effects of a fish oil- (FO-) based lipid emulsion on muscle leukocyte chemotaxis and inflammatory responses in a murine model of limb ischemia-reperfusion (IR) injury.
Mice were assigned randomly to 1 sham (sham) group, 2 ischemic groups, and 2 IR groups.
The sham group did not undergo the ischemic procedure.
The mice assigned to the ischemic or IR groups were pretreated intraperitoneally with either saline or FO-based lipid emulsion for 3 consecutive days.
The IR procedure was induced by applying a 4.5 oz orthodontic rubber band to the left thigh above the greater trochanter for 120 min and then cutting the band to allow reperfusion.
The ischemic groups were sacrificed immediately while the IR groups were sacrificed 24 h after reperfusion.
Blood, IR-injured gastrocnemius, and lung tissues were collected for analysis.
The results showed that FO pretreatment suppressed the local and systemic expression of several IR-induced proinflammatory mediators.
Also, the FO-pretreated group had lower blood L y 6 C h i C C R 2 h i monocyte percentage and muscle M1/M2 ratio than the saline group at 24 h after reperfusion.
These findings suggest that FO pretreatment may have a protective role in limb IR injury by modulating the expression of proinflammatory mediators and regulating the polarization of macrophage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shih, Yao-Ming& Shih, Juey-Ming& Hou, Yu-Chen& Yeh, Chiu-Li& Li, Cheng-Che& Yeh, Sung-Ling. 2017. Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188375
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shih, Yao-Ming…[et al.]. Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188375
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shih, Yao-Ming& Shih, Juey-Ming& Hou, Yu-Chen& Yeh, Chiu-Li& Li, Cheng-Che& Yeh, Sung-Ling. Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188375
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188375
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر