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Comparison of Antidiabetic Medications during the Treatment of Atherosclerosis in T2DM Patients
المؤلفون المشاركون
Liu, Xiaojie
Mei, Tao
Chen, Wei
Ye, Shandong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Type 2 diabetes is often associated with arterial atherosclerosis in large blood vessels.
We set out to elucidate whether commonly used antidiabetic drugs metformin, sitagliptin, and pioglitazone will reduce atherosclerosis in T2DM patients.
We enrolled 176 individuals with type 2 diabetes, which were divided into four treatment groups according to different oral drugs: metformin alone, sitagliptin alone, pioglitazone alone, or combination of metformin and sitagliptin.
We assessed changes in glycometabolism, lipid metabolism, cytokine released, and carotid artery intima-media thickness as the readout for improvement in atherosclerosis.
HbA1c levels were significantly decreased in all treatment groups (p<0.05), and FBG levels were also decreased in metformin and combined groups (p<0.05).
In addition, we found IL-6 levels significantly decreased in all treatment groups (p<0.05).
Treatment with pioglitazone showed a significant increase in BMI, HDL, and ADPN levels (p<0.05).
We also observed a significant decrease in NHDL levels in the combined treatment group (p<0.05).
Our data revealed that in addition to hypoglycemic properties of metformin, sitagliptin, and pioglitazone, these drugs also have the potential to promote an anti-inflammatory response.
Therefore, combination therapy may be more beneficial for reducing atherosclerosis in patients with type 2 diabetes.
The clinical trial is registered with ChiCTR-ORC-17010835.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xiaojie& Mei, Tao& Chen, Wei& Ye, Shandong. 2017. Comparison of Antidiabetic Medications during the Treatment of Atherosclerosis in T2DM Patients. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188377
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xiaojie…[et al.]. Comparison of Antidiabetic Medications during the Treatment of Atherosclerosis in T2DM Patients. Mediators of Inflammation No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1188377
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xiaojie& Mei, Tao& Chen, Wei& Ye, Shandong. Comparison of Antidiabetic Medications during the Treatment of Atherosclerosis in T2DM Patients. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1188377
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188377
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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