In Vivo Evaluation of the Antitumor and Immunogenic Properties of Silver and Sodium Dichloroacetate Combination against Melanoma

المؤلفون المشاركون

Rodríguez-Padilla, Cristina
Zamora-Ávila, Diana Elisa
Torres-Cavazos, Zaida
Franco-Molina, Moisés Armides
Santana-Krímskaya, Silvia Elena
Kawas-Garza, Jorge Ramsy
Moreno-Degollado, Gustavo
Hernández-Vidal, Gustavo

المصدر

Journal of Nanomaterials

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-11-07

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

Our main focus was to evaluate the efficacy of silver and sodium dichloroacetate as dual-function agents to be used in melanoma treatment.

This strategy is designed to increase the activity of these two compounds that affect DNA integrity and the mitochondria at different levels.

Furthermore, we evaluated if the cell death mechanism induced by our treatments was immunogenic cell death.

To evaluate antitumor efficacy, we assessed tumor volume and production of tumor necrosis factor-α, nuclear factor κ B (both by ELISA), and nitric oxide levels (Nitrate/Nitrite colorimetric assay kit); for immunogenic cell death, we evaluated the release of danger-associated molecular patterns using immunohistochemistry and flow cytometry, as well as an in vivo challenge.

Our results showed that the combination of colloidal silver and sodium dichloroacetate is more effective than each treatment alone and that the antitumor mechanism is not through immunogenic cell death.

Furthermore, this study can broadly contribute to the development of dichloroacetate-loaded silver nanoparticles and to the design targeted pharmacological formulations to fight melanoma as well as other types of cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Torres-Cavazos, Zaida& Franco-Molina, Moisés Armides& Santana-Krímskaya, Silvia Elena& Rodríguez-Padilla, Cristina& Hernández-Vidal, Gustavo& Zamora-Ávila, Diana Elisa…[et al.]. 2020. In Vivo Evaluation of the Antitumor and Immunogenic Properties of Silver and Sodium Dichloroacetate Combination against Melanoma. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188400

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hernández-Vidal, Gustavo…[et al.]. In Vivo Evaluation of the Antitumor and Immunogenic Properties of Silver and Sodium Dichloroacetate Combination against Melanoma. Journal of Nanomaterials No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1188400

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Torres-Cavazos, Zaida& Franco-Molina, Moisés Armides& Santana-Krímskaya, Silvia Elena& Rodríguez-Padilla, Cristina& Hernández-Vidal, Gustavo& Zamora-Ávila, Diana Elisa…[et al.]. In Vivo Evaluation of the Antitumor and Immunogenic Properties of Silver and Sodium Dichloroacetate Combination against Melanoma. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188400

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1188400