Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats
المؤلفون المشاركون
Wang, Liangrong
Chen, Feifei
Pan, Yafei
Lin, Lina
Xiong, Xiangqing
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process.
We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats.
Methods.
Fifty Sprague-Dawley rats were divided into groups SM, IR, F3, F5, and F10.
Group SM received sham operation, and bilateral hindlimb IR was established in group IR.
The rats in groups F3, F5, and F10 were pretreated with 3, 5, and 10 mg/kg/d FTY720 for 7 days before IR.
S1P lyase (S1PL), sphingosine kinase (SphK) 1, and SphK2 mRNA expressions, wet/dry weight (W/D), and polymorphonuclear/alveolus (P/A) in lung tissues were detected, and the lung injury score was evaluated.
Results.
W/D, P/A, and mRNA expressions of S1PL, SphK1, and SphK2 were higher in group IR than in group SM, while these were decreased in both groups F5 and F10 as compared to IR (p<0.05).
The lung tissue presented severe lesions in group IR, which were attenuated in groups F5 and F10 with lower lung injury scores than in group IR (p<0.05).
Conclusions.
FTY720 pretreatment could attenuate lung injury induced by hindlimb IR by modulating S1P metabolism and decreasing pulmonary neutrophil infiltration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Liangrong& Chen, Feifei& Pan, Yafei& Lin, Lina& Xiong, Xiangqing. 2017. Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188431
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Liangrong…[et al.]. Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188431
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Liangrong& Chen, Feifei& Pan, Yafei& Lin, Lina& Xiong, Xiangqing. Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188431
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188431
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر