![](/images/graphics-bg.png)
Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses?
المؤلفون المشاركون
Yu, Zhigang
Liu, Lu
Zhou, Fei
Wang, Pin
Yu, Lixiang
Ma, Zhongbing
Li, Yuyang
Gao, Dezong
Zhang, Qiang
Li, Liang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Periductal mastitis (PDM) is a prolonged inflammatory disease, but the cause of PDM is poorly understood.
In the present case control study, 87 PDM and 87 healthy controls were enrolled and the results were evaluated to identify the significant risk factors for PDM.
To investigate the roles of bacterial infection and critical cytokines expression, 16S rRNA gene sequencing and bacterial culturing were conducted.
We also measured the levels of interferon-γ, interleukin-12A, and interleukin-17A by semiquantitative immunohistochemistry method.
In a multivariable logistic regression model, we identified overweight/obesity and late onset of menarche as independent risk factors for PDM.
In contrast, age of first birth >27 years had a protective effect.
With 16S rRNA gene sequencing, we confirmed bacterial infections were found in all PDM patients, but none of the control patients was positive on the gene expression of 16S rRNA.
Our results also demonstrated significant increases of the IFN-γ and IL-12A expression in PDM, but there was no difference in IL-17A expression in these two groups.
Taken together, this study suggests that reproductive factors and overweight/obesity are possible predisposing risk factors for PDM.
Bacterial infection and the increased expression of some proinflammatory cytokines are associated with the pathogenesis of this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Lu& Zhou, Fei& Wang, Pin& Yu, Lixiang& Ma, Zhongbing& Li, Yuyang…[et al.]. 2017. Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses?. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Lu…[et al.]. Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses?. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Lu& Zhou, Fei& Wang, Pin& Yu, Lixiang& Ma, Zhongbing& Li, Yuyang…[et al.]. Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses?. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)