![](/images/graphics-bg.png)
Neutrophil Extracellular DNA Traps Induce Autoantigen Production by Airway Epithelial Cells
المؤلفون المشاركون
Kim, Seung-Hyun
Ban, Ga-Young
Choi, Youngwoo
Pham, Le Duy
Lee, Dong-Hyun
Lee, Ji-Ho
Park, Hae-Sim
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The hypothesis of autoimmune involvement in asthma has received much recent interest.
Autoantibodies, such as anti-cytokeratin (CK) 18, anti-CK19, and anti-α-enolase antibodies, react with self-antigens and are found at high levels in the sera of patients with severe asthma (SA).
However, the mechanisms underlying autoantibody production in SA have not been fully determined.
The present study was conducted to demonstrate that neutrophil extracellular DNA traps (NETs), cytotoxic molecules released from neutrophils, are a key player in the stimulation of airway epithelial cells (AECs) to produce autoantigens.
This study showed that NETs significantly increased the intracellular expression of tissue transglutaminase (tTG) but did not affect that of CK18 in AECs.
NETs induced the extracellular release of both tTG and CK18 in a concentration-dependent manner.
Moreover, NETs directly degraded intracellular α-enolase into small fragments.
However, antibodies against neutrophil elastase (NE) or myeloperoxidase (MPO) attenuated the effects of NETs on AECs.
Furthermore, each NET isolated from healthy controls (HC), nonsevere asthma (NSA), and SA had different characteristics.
Taken together, these findings suggest that AECs exposed to NETs may exhibit higher autoantigen production, especially in SA.
Therefore, targeting of NETs may represent a new therapy for neutrophilic asthma with a high level of autoantigens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Youngwoo& Pham, Le Duy& Lee, Dong-Hyun& Ban, Ga-Young& Lee, Ji-Ho& Kim, Seung-Hyun…[et al.]. 2017. Neutrophil Extracellular DNA Traps Induce Autoantigen Production by Airway Epithelial Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Youngwoo…[et al.]. Neutrophil Extracellular DNA Traps Induce Autoantigen Production by Airway Epithelial Cells. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Youngwoo& Pham, Le Duy& Lee, Dong-Hyun& Ban, Ga-Young& Lee, Ji-Ho& Kim, Seung-Hyun…[et al.]. Neutrophil Extracellular DNA Traps Induce Autoantigen Production by Airway Epithelial Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)