Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3KAktmTOR Signaling Suppression
المؤلفون المشاركون
Zhong, Jixin
Xu, Jun-Fa
Zheng, Xue-Bao
Fu, Xiaoxia
Sun, Fei
Wang, Faxi
Zhang, Junai
Zheng, Biying
Yue, Tiantian
Wang, Cong-Yi
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Colitis is a major form of inflammatory bowel disease which involved mucosal immune dysfunction.
Aloperine is an alkaloid isolated from the shrub Sophora alopecuroides L.
and has been recognized as an effective treatment for inflammatory and allergic diseases.
The present study aimed to examine the molecular mechanisms underlying aloperine-mediated colitis protection.
We found that aloperine treatment improved colitis induced by dextran sodium sulfate (DSS) based on body weight, disease activity index, colonic length, and spleen index.
Aloperine also effectively attenuated DSS-induced intestinal inflammation based on the pathological score and myeloperoxidase expression and activity in colon tissues.
In addition, aloperine regulated T-cell proportions and promoted Foxp3 expression in the spleens and mesenteric lymph nodes of DSS-induced colitis mice and in the spleens of the Foxp3GFP mice.
Aloperine inhibited Jurkat and mouse naïve T-cell apoptosis.
Furthermore, aloperine inhibited PI3K/Akt/mTOR signaling and upregulated PP2A expression in the DSS-induced colitis mice and in Jurkat cells, but LB-100 (PP2A inhibitor) resulted in an elevated Akt activity in Jurkat cells, activated T-cells, and human splenic mononuclear cells.
Aloperine inhibited T-cell and lymphocyte proliferation, but LB-100 reverse these effects.
In conclusion, aloperine regulates inflammatory responses in colitis by inhibiting the PI3K/Akt/mTOR signaling in a PP2A-dependent manner.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Xiaoxia& Sun, Fei& Wang, Faxi& Zhang, Junai& Zheng, Biying& Zhong, Jixin…[et al.]. 2017. Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3KAktmTOR Signaling Suppression. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Xiaoxia…[et al.]. Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3KAktmTOR Signaling Suppression. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Xiaoxia& Sun, Fei& Wang, Faxi& Zhang, Junai& Zheng, Biying& Zhong, Jixin…[et al.]. Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3KAktmTOR Signaling Suppression. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر