Interluekin-35 in Asthma and Its Potential as an Effective Therapeutic Agent
المؤلفون المشاركون
Zhang, Jie
Gao, Peng
Su, Zhenzhong
Lv, Xuejiao
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Interleukin- (IL-) 35 is a member of the IL-12 cytokine family and a heterodimeric protein formed by Epstein-Barr-induced gene 3 (EBI3) and IL-12p35.
Emerging evidence shows that IL-35 is a key player in the regulation of cellular communication, differentiation, and inflammation.
Altered IL-35 expression has been found in disease conditions such as cancer, rheumatoid arthritis, and, more recently, asthma.
In cancer, IL-35 is involved in the regulation of tumorigenesis, cancer progression, and metastasis.
In rheumatoid arthritis, IL-35 acts as a negative regulator of inflammation.
Similarly, IL-35 also appears to suppress allergic inflammation in asthma.
In an in vivo murine model of asthma, transfer of adenovirus-mediated IL-35 markedly reduced the degree of airway hyperresponsiveness (AHR) and inflammatory cell infiltration.
Many studies have shown the involvement of IL-35 in a number of aspects of allergic inflammation, such as eosinophil and neutrophil recruitment as well as inhibition of inflammatory mediators of the Th2 subtype.
However, the exact molecular mechanisms underlying the role of IL-35 in human asthma have yet to be fully elucidated.
This review describes the current evidence regarding the role of IL-35 in the pathophysiology of asthma and evaluates the potential of IL-35 as a biomarker for airway inflammation and a therapeutic target for the treatment of asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Peng& Su, Zhenzhong& Lv, Xuejiao& Zhang, Jie. 2017. Interluekin-35 in Asthma and Its Potential as an Effective Therapeutic Agent. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Peng…[et al.]. Interluekin-35 in Asthma and Its Potential as an Effective Therapeutic Agent. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Peng& Su, Zhenzhong& Lv, Xuejiao& Zhang, Jie. Interluekin-35 in Asthma and Its Potential as an Effective Therapeutic Agent. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر