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Functionalization of Graphene Oxide Nanosheets Can Reduce Their Cytotoxicity to Dental Pulp Stem Cells
المؤلفون المشاركون
Gholami, Ahmad
Emadi, Fatemeh
Amini, Abbas
Shokripour, Mansoureh
Chashmpoosh, Mostafa
Omidifar, Navid
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
The dental pulp is a heterogeneous soft tissue that supplies nutrients and acts as a biosensor to identify pathogenic stimuli.
Regeneration of the dental pulp is one of the desirable topics for researchers.
Graphene oxide nanosheets (nGOs) help overexpression of the genes related to odontogenic differentiation of stem cells from dental pulps and increases attachment and proliferation of dental pulp stem cells.
Despite its benefits, nGO may be considered as a threat to the environment and human health.
Therefore, the purpose of this study was to evaluate the biocompatibility potential of graphene oxide (nGO), chitosan functionalized graphene oxide (nGO-CS), and carboxylated graphene (nGO-COOH) when exposed to human dental pulp stem cells (hDPSCs).
Material and Methods.
Some different aspects of biocompatibility of nGO, nGO-CS, and nGO-COOH were synthesized, and several intracellular effects induced by different concentrations of graphene-based nanosheets, including cell viability, intracellular oxidative damages, and various factors such as LDH, GSH, SOD, MDA, and MMP, were studied on hDPSCs.
Results.
According to results, IC50 was determined as 232.01, 467.81, and ≥1000 μg/mL for nGO, nGO-CS, and nGO-COOH, respectively.
These results demonstrated the lower toxicity and higher cytocompatibility of nGO-CS and nGO-COOH compared to nGO.
nGO-COOH not only has any adverse effect on the cell membrane and mitochondrial activity but also shows slight antioxidant activity at some concentrations.
Conclusion.
The findings help design safe and cytocompatible nGO derivatives for biomedical applications in dental fields.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gholami, Ahmad& Emadi, Fatemeh& Amini, Abbas& Shokripour, Mansoureh& Chashmpoosh, Mostafa& Omidifar, Navid. 2020. Functionalization of Graphene Oxide Nanosheets Can Reduce Their Cytotoxicity to Dental Pulp Stem Cells. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1188528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gholami, Ahmad…[et al.]. Functionalization of Graphene Oxide Nanosheets Can Reduce Their Cytotoxicity to Dental Pulp Stem Cells. Journal of Nanomaterials No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1188528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gholami, Ahmad& Emadi, Fatemeh& Amini, Abbas& Shokripour, Mansoureh& Chashmpoosh, Mostafa& Omidifar, Navid. Functionalization of Graphene Oxide Nanosheets Can Reduce Their Cytotoxicity to Dental Pulp Stem Cells. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1188528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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