A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse
المؤلفون المشاركون
Wright, Craig Robert
Allsopp, Giselle Larissa
Addinsall, Alex Bernard
McRae, Natasha Lee
Andrikopoulos, Sofianos
Stupka, Nicole
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Excessive inflammation is a hallmark of muscle myopathies, including Duchenne muscular dystrophy (DMD).
There is interest in characterising novel genes that regulate inflammation due to their potential to modify disease progression.
Gene polymorphisms in Selenoprotein S (Seps1) are associated with elevated proinflammatory cytokines, and in vitro SEPS1 is protective against inflammatory stress.
Given that SEPS1 is highly expressed in skeletal muscle, we investigated whether the genetic reduction of Seps1 exacerbated inflammation in the mdx mouse.
F1 male mdx mice with a heterozygous Seps1 deletion (mdx:Seps1−/+) were generated.
The mdx:Seps1−/+ mice had a 50% reduction in SEPS1 protein expression in hindlimb muscles.
In the extensor digitorum longus (EDL) muscles, mRNA expression of monocyte chemoattractant protein 1 (Mcp-1) (P=0.034), macrophage marker F4/80 (P=0.030), and transforming growth factor-β1 (Tgf-β1) (P=0.056) were increased in mdx:Seps1−/+ mice.
This was associated with a reduction in muscle fibre size; however, ex vivo EDL muscle strength and endurance were unaltered.
In dystrophic slow twitch soleus muscles, SEPS1 reduction had no effect on the inflammatory profile nor function.
In conclusion, the genetic reduction of Seps1 appears to specifically exacerbate the inflammatory profile of fast-twitch muscle fibres, which are typically more vulnerable to degeneration in dystrophy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wright, Craig Robert& Allsopp, Giselle Larissa& Addinsall, Alex Bernard& McRae, Natasha Lee& Andrikopoulos, Sofianos& Stupka, Nicole. 2017. A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wright, Craig Robert…[et al.]. A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wright, Craig Robert& Allsopp, Giselle Larissa& Addinsall, Alex Bernard& McRae, Natasha Lee& Andrikopoulos, Sofianos& Stupka, Nicole. A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر