Th1Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris
المؤلفون المشاركون
Vinícius da Silva, Marcos
de Oliveira, Carlo Jose Freire
Sales-Campos, Helioswilton
Miguel, Camila Botelho
Silva, Djalma A. A.
Rodrigues Junior, Virmondes
Timoteo, Rodolfo Pessato
Catarino, Jonatas Da Silva
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3.
Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored.
Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease.
Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum.
PV patients had higher levels of inflammatory Th1/Th17 cytokines (IFN-γ, IL-17, and IL-23), as well as higher levels of CXCL8 and reduced levels of Th1/Th2-related chemokines (IP-10 and CCL11).
However, no differences in the levels of IL-2, IL-6, TNF-α, IL-1β, IL-4, IL-9, IL-12, TGF-β, IL-33, MCP-1, RANTES, and MIP-1α were found between PV patients and their control counterparts.
Furthermore, PV patients with skin lesions had higher serum levels of IL-6 and CXCL8 when compared to PV patients without lesions.
Taken together, our findings describe the role of cytokines and chemokines associated with Th1/Th17 immune response in PV patients.
Finally, these data are important for better understanding of the immune aspects that control disease outcome, and they may also provide important information about why patients develop autoantibodies against desmogleins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Timoteo, Rodolfo Pessato& Vinícius da Silva, Marcos& Miguel, Camila Botelho& Silva, Djalma A. A.& Catarino, Jonatas Da Silva& Rodrigues Junior, Virmondes…[et al.]. 2017. Th1Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Timoteo, Rodolfo Pessato…[et al.]. Th1Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Timoteo, Rodolfo Pessato& Vinícius da Silva, Marcos& Miguel, Camila Botelho& Silva, Djalma A. A.& Catarino, Jonatas Da Silva& Rodrigues Junior, Virmondes…[et al.]. Th1Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر