Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation
المؤلفون المشاركون
Kusmenkov, T.
Biberthaler, P.
Bogner, V.
Kanz, Karl Georg
Braunstein, Mareen
Böcker, Wolfgang
Williamson, Martina
Landes, Jürgen
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Introduction.
The purpose of this study was to evaluate immediate immunological changes following cardiopulmonary resuscitation (CPR).
mRNA expression levels of selected immunomodulatory cytokines in out-of-hospital cardiac arrest (OHCA) survivors were detected and correlated to clinical parameter.
Methods.
OHCA survivors with sustained unconsciousness after return of spontaneous circulation (ROSC) were included.
PAXgene whole blood samples were drawn immediately after initiation of CPR and subsequently after 6 h, 12 h, 24 h, 48 h, and 72 h.
TNF-alpha, IL-8, IL-10, and IL-1ra mRNA levels were quantified by RT-qPCR and compared to multiple organ failure, 30-day survival, and the induction of therapeutic hypothermia (TH).
Results.
25 patients (63 ± 15 years) were enrolled presenting a characteristic time-dependent cytokine profile in the early postresuscitation period.
High initial TNF-alpha and IL-8 mRNA levels were followed by a significant decrease.
IL-1ra mRNA levels significantly increased beginning after 6 h.
Nonsurvivors showed significantly higher IL-8 mRNA levels immediately after CPR.
TH induced significantly higher IL-1ra mRNA levels compared to normothermia.
Conclusion.
Significant mRNA cytokine expression changes are already detectable immediately after initiation of CPR.
These expressional changes are significantly different depending on 30-day survival.
TH seems to attenuate proinflammatory immune reaction by a significant increase of IL-1ra mRNA levels.
This trial is registered with DRKS00012940.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Braunstein, Mareen& Williamson, Martina& Kusmenkov, T.& Landes, Jürgen& Biberthaler, P.& Kanz, Karl Georg…[et al.]. 2017. Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Braunstein, Mareen…[et al.]. Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Braunstein, Mareen& Williamson, Martina& Kusmenkov, T.& Landes, Jürgen& Biberthaler, P.& Kanz, Karl Georg…[et al.]. Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر